Production by microbiological fermentation of a concentrate having vitamin B12 activity (with observations on the assay methods used).
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Production by microbiological fermentation of a concentrate having vitamin B12 activity (with observations on the assay methods used).

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Published .
Written in English


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Edition Notes

Thesis (M.A.) -- University of Toronto, 1951.

The Physical Object
Pagination1 v.
ID Numbers
Open LibraryOL20116426M

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  During the four years which have passed since the microbiological fermentation of vitamin B12 complex was first accomplished, major developments have occurred, and the production of vitamin B12 and its various complexes has become a major fermentation industry with substantial markets in human and animal nutrition. Factors which have contributed to the highly successful Cited by: Vitamin B12 is produced industrially by microbial fermentation, using almost exclusively Pseudomonas denitrificans and Propionibacterium species (as reviewed by Spalla et al, “Microbial production of vitamin B12”, In: Biotechnology of vitamins, pigments and growth factors, E. J. Vandamme ed., Elsevier, London, N.Y., pp. ).   Vitamin B12 is produced industrially by microbial fermentation, using almost exclusively Pseudomonas denitrificans and Propionibacterium species as described in Japanese Patent , then converting the natural vitamin B12 into the cyanocobalamin form by chemical processes including cyanidization followed by extraction and purification steps using organic solvents (as reviewed by Spalla et al., "Microbial production of vitamin B While over fermentation processes have been described for the production of vitamin Bl2 only half a dozen have apparently been used on a commercial scale. Fermentation processes using Bacillus megatherium, Streptomyces olivaceus and other species, Propionibacterium freundreichii, .

  It is produced biologically from Pseudomonas and Propionibacterium fermentation (10 t/a, Rhône-Poulenc, Aventis). 2 On the one hand, in the case of Propionibacterium shermanii, the vitamin is produced in two steps: (1) bacterial growth and the production of intermediates and (2) the production of vitamin B12 from corn steep liquor, glucose and. Vitamin B 12, also known as cobalamin, comprises a number of forms including cyano-, methyl-, deoxyadenosyl- (coenzyme B 12), and hydroxy-cobalamin. Note that the mineral cobalt is an essential part of the B The cyano- form produced by fermentation is supplemented in feed as a dry dilution having 1% activity.   In book: Microbial sources of vitamins: In Comprehensive Food Fermentation Biotechnology (pp) fermentation of vitamin B. 6. vitamin B12 production was increased from to Vitamin B 12 in Human Nutrition: Milk is a Major Source. Among B vitamins, vitamin B 12 occupies a very special niche. This vitamin is produced only by bacteria and archaebacteria if the cobalt supply is adequate. As opposed to other B vitamins, it is neither synthesized nor used by fungi and plants (Martens et al., ).Therefore, in human diets, the sole natural source of vitamin B 12 comes.

  Vitamin B12(Cobalamin) Is a complex biochemical structure, but is water soluble One of the most alluring and fascinating molecules in the world of science and medicine is Vitamin B12 Vitamin B12 is unique among the vitamins in being synthesized almost exclusively by Microorganisms Minot and Murphy- demonstrated that they were able to cure. Microbial production has become a dominant method to generate various substances, such as amino acids (Wendisch, ), organic acids (Alonso et al., ), and vitamins (Ami et al., ). To. Vitamin B12 or riboflavin can be opted in foods which are not fortified (the foods which have no added micronutrients other than natural) like milk, eggs, cheese, leafy vegetables, mushrooms, etc. Deficiency can be caused by less intake of B2 food. The formula for vitamin B2 is C 17 H 20 N 4 O 6.   In relation to the additive formulated at 1% vitamin B12, the fractions of particles having a diameter.